MRI-measured transverse relaxation time (T 2) and 1RM of seated/prone leg curl were assessed before, 24, 48, and 72 h after exercise. Part 2: Nineteen participants from part 1 and another 12 untrained controls (Control-Leg) performed eccentric phase-only leg curl exercise at 90% 1RM, 10 repetitions per set, 3 sets for each of the seated/prone conditions with each leg. Magnetic resonance imaging (MRI)–measured muscle volume of the individual and whole hamstrings was assessed pre- and posttraining. Part 1: Twenty healthy adults conducted seated leg curl training with one leg (Seated-Leg) and prone with the other (Prone-Leg), at 70% one-repetition maximum (1RM), 10 repetitions per set, 5 sets per session, 2 sessions per week for 12 wk. We investigated the effects of seated versus prone leg curl training on hamstrings muscle hypertrophy and susceptibility to eccentric exercise-induced muscle damage. The biarticular hamstrings are lengthened more in a seated (hip-flexed) than prone (hip-extended) position. The work cannot be changed in any way or used commercially without permission from the journal. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site ( This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. Supplemental digital content is available for this article. 1Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, JAPANĢCollege of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, JAPANģRitsumeikan Global Innovation Research Organization, Ritsumeikan University, Kusatsu, Shiga, JAPANĪddress for correspondence: Sumiaki Maeo, Ph.D., Research Organization of Science and Technology, Ritsumeikan University, 1-1-1, Nojihigashi, Kusatsu, Shiga 525-8577, Japan E-mail.
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